萧雨芬博士
邮箱: yufenxiao@ecust.edu.cn；联系电话: 15021797103
个人简介
萧雨芬，太阳成集团tyc33455cc特聘研究员，国家级高层次青年人才项目获得者。于2015，2018及2021年分别在同济大学获得学士、硕士及博士学位，师从杜建忠教授。2019至2021年期间赴哈佛医学院联合培养，师从Omid Farokhzad院士和陶伟教授。2022年起，赴德克萨斯大学西南医学中心Daniel Siegwart院士课题组进行博士后研究，随后在该校生物医学工程系担任讲师。目前任职于太阳成集团tyc33455特聘研究员。长期专注于高分子化学和生物医用材料研究，在糖尿病、癌症治疗等领域积累了扎实的基础，取得了独具特色的原创性成果，目前在Nat. Mater., J. Am. Chem. Soc., Angew. Chem. Int. Ed., PNAS; Matter等权威期刊以第一作者、通讯作者发表论文17篇。目前的研究方向集中生物医用高分子材料、核酸递送、癌症治疗、糖尿病等代谢性疾病治疗。
科研与学术工作经历
特聘研究员 2026.3至今
太阳成集团tyc33455cc 太阳成集团tyc33455 上海,中国
讲师 2024.12 - 2026.2
University of Texas Southwestern Medical Center德克萨斯大学西南医学中心 达拉斯,德克萨斯州,美国
博士后研究员 2022.3 - 2024.12
University of Texas Southwestern Medical Center 德克萨斯大学西南医学中心 达拉斯,德克萨斯州,美国
导师: Daniel J. Siegwart教授
博士后研究员 2021.12 - 2022.3
Brigham and Women’s Hospital/Harvard Medical School布莱根妇女医院/哈佛医学院波士顿,马萨诸塞州,美国
导师: Wei Tao教授
教育经历
联合培养博士2019.12- 2021.11
Brigham and Women’s Hospital/Harvard Medical School 布莱根妇女医院/哈佛医学院波士顿,马萨诸塞州,美国
导师: Omid C. Farokhzad教授, Wei Tao教授
工学学士、硕士、博士 材料科学与工程 2011.9- 2021.11
同济大学 上海, 中国
导师: 杜建忠 教授
已发表论文
(被引次数: >3700, h指数: 29; i10指数: 30, Google Scholar)
第一及通讯作者论文
1. Y. Xiao, X. Lian, Y. Sun, Y. Sung, A. Vaidya, Z. Chen, A. Gupta, S. Chatterjee, L. Zheng, E. Guerrero, X. Wang, L. Farbiak, Y. Yang, M. I. Diamond, C. Leal, J. G. McDonald, D. J. Siegwart,* High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics. Nature Materials, 2025, 24, 1840-1851.
亮点报道：Editorial, Comment, and News & Views in the same issue as a research focus entitled “PEG alternatives for RNA therapeutics” in Nature Materials:
PEG alternatives for RNA therapeutics. Nature Materials, 2025, 24, 1665.
K.A. Whitehead* et al. Designing around immune memory to counter PEG immunogenicity. Nature Materials, 2025, 24, 1666–1669.
L.Zhang* et al. Making way for PEG alternatives. Nature Materials, 2025, 24, 1682–1683.
C. Liu* et al. Breaking the PEG barrier to boost mRNA-LNP therapeutics. Nature Reviews Materials, 2025, 10, 799–800.
P. Gurnani* et al. Mushrooms to brushes: Tackling the PEG dilemma in mRNA lipid nanoparticles with complex polymers, Matter, 2025, 8, 102386; Stemcell science news.
2. Y. Xiao, H. Sun, J. Du*. Sugar-breathing glycopolymersomes for regulating glucose level. Journal of the American Chemical Society, 2017, 139 (22): 7640-7647. DOI: 10.1021/jacs.7b03219
亮点报道：ACS Press; Chemical & Engineering News: C & EN 2017, 95, 23, 9; Medical News Today; Science Daily; Health Medicinet; MedPage Today; Science Newsline; The Medical News; EurekAlert!; Phys.org;
3. Y. Xiao, Z. Tang,J. Wang, C. Liu, N. Kong, O. C. Farokhzad*, W. Tao*. Oral insulin delivery platforms: Strategies to address the biological barriers. Angewandte Chemie International Edition, 2020, 59 (45): 19787-19795. (背封面)DOI: 10.1002/anie.202008879
4. Y. Xiao, Z. Tang, X. Huang, J. Joseph, W. Chen, C. Liu, J. Zhou, N. Kong, N. Joshi, J. Du, W. Tao*. Glucose-responsive oral insulin delivery platform for one-treatment-a-day in diabetes. Matter, 2021, 4 (10): 3269-3285.DOI: 10.1016/j.matt.2021.08.011
Highlighted by Gu* et al. Smart oral insulin therapy, Matter, 2021, 4, 3790-3791.
5. Y. Xiao, Y. Hu, J. Du*. Controlling blood sugar levels with a glycopolymersome. Materials Horizons, 2019, 6 (10): 2047-2055. DOI: 10.1039/c9mh00625g
6. Y. Xiao*, J. Zhang, T. Wu, S. Chen, Z. Huang, J. Du*. Three-day blood glucose control via a glucose modulator of glycopolymersome: Sugar versus sugar.Chemistry of Materials, 2024, 36 (5): 2420–2431. (第一作者兼共同通讯作者，封面)DOI: 10.1021/acs.chemmater.3c03140
7. Y Xiao, Z. Tang, J. Zhang, Q. Saiding, Y. Li, J. Du*, Wei Tao* One-pot synthesis of Fe-norepinephrine nanoparticles for synergetic thermal-enhanced chemodynamic therapy. Nano Letters, 2024, 24 (43): 13825–13833. (补充封面)DOI: 10.1021/acs.nanolett.4c04375
8. Y. Xiao, Z. Tang,X. Huang,W. Chen,J. Zhou, H. Liu, C. Liu, N. Kong, O. C. Farokhzad*, W. Tao*. Emerging mRNA technologies: delivery strategies and biomedical applications.Chemistry Society Review, 2022, 51 (10): 3828-3845. (封面, 高被引论文)DOI: 10.1039/d1cs00617g
9. Z. Huang, J. Zhang, Y. Qian, H. Liu, Y. Xiao*, J. Du*, Antioxidant glycopolymersomes with dynamic covalent glucose regulation for synergistic pancreatitis-diabetes therapy, Nano Today, 2025, 65, 102871. DOI: 10.1016/j.nantod.2025.102871
10. W. Zhang, Z. Ge, Y. Xiao*, D. Liu*, J. Du*. Antioxidant and immunomodulatory polymer vesicles for effective diabetic wound treatment through ROS scavenging and immune modulating. Nano Letters, 2024,24 (31): 9494–9504.DOI: 10.1021/acs.nanolett.4c01869
11. B. Jia, B. Zhang, J. Li, J. Qin, Y. Huang, M. Huang, Y. Ming, J. Jiang, R. Chen, Y. Xiao* and J. Du*. Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment. Chemistry Society Review, 2024, 53 (7): 3273-3301. (Inside Front Cover)DOI: 10.1039/d3cs01039b
12. Z. Tang, X. You, Y. Xiao (共同第一作者), W. Chen, Y. Li, X. Huang, H. Liu, F. Xiao, C. Liu, S. Koo, N. Kong, W. Tao*. Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection. Proceedings of the National Academy of Sciences, 2023, 120 (44): e2304966120. DOI: 10.1073/pnas.2304966120
13. P. Zhang,Y. Xiao(共同第一作者), X. Sun, X. Lin, S. Koo, A. Yaremenko, D. Qin, N. Kong, O. C. Farokhzad, W. Tao*. Cancer nanomedicine toward clinical translation: Obstacles, opportunities, and future prospects. Med, 2023, 4 (3): 147-167.DOI: 10.1016/j.medj.2022.12.001
14. Y. Xiao, J. Du*. Superparamagnetic nanoparticles for biomedical applications. Journal of Materials Chemistry B, 2020, 8(3): 354-367.DOI: 10.1039/c9tb01955c
15. P. Gao, Y. Xiao(共同第一作者), L. Li*, W. Li*, W. Tao*. Biomedical applications of 2D monoelemental materials formed by group VA and VIA: a concise review. Journal of Nanobiotechnology, 2021, 19 (1): 1-23.DOI: 10.1186/s12951-021-00825-4
16. Y. Xiao*. Editorial: Nanodrug delivery strategies for enhanced cancer chemo-immunotherapy.Frontiers in Bioengineering and Biotechnology, 2025, 13.DOI: 10.3389/fbioe.2025.1653425
17. Y. Xiao, J. Chen*, C. Wang*, W. Tao*. Emerging Micro-and Nanotechnologies for Medical and Pharmacological Applications. Frontiers in Pharmacology, 2021, 12. DOI: 10.3389/fphar.2021.6487499.
其余论著
18. A. Vaidya, Y. Sung, V. T. Tcheuyap, C. Zhang, R. Butti, A. Mal, S. Dilliard, J. Liu, E. Song, E. Guerrero, P. Patel, J. Santelli, J. Miyata, S. Moore, S. Chatterjee, G. Prakasam, Y. Xiao, P. Kapur, J. Brugarolas, D. J. Siegwart*. Endogenous targeting of lipid nanoparticles to kidney tumors. ACS Nano, 2025, 19 (34): 30860-30871. DOI: 10.1021/acsnano.5c05370
19. S. Wu, Y. Yang, X. Lian, F. Zhang, C. Hu, J. Tsien, Z. Chen, Y. Sun, A. Vaidya, M. Kim, Y. Sung, Y. Xiao, X. Bian, X. Wang, Z. Tian, E. Guerrero, J. Robinson, P. Basak, T. Qin*, D. J. Siegwart*. Isosteric 3D Bicyclo[1.1.1]Pentane (BCP) Core-Based Lipids for mRNA Delivery and CRISPR/Cas Gene Editing. Journal of the American Chemical Society, 2024, 146 (50): 34733–34742. DOI: 10.1021/jacs.4c13154
20. Y. Sun, S. Chatterjee, X. Lian, Z. Traylor, S. R. Sattiraju, Y. Xiao, S. A. Dilliard, Y. Sung, M. Kim, S. M. Lee, S. Moore, X. Wang, D. Zhang, S. Wu, P. Basak, J. Wang, J. Liu, R. J. Mann, D. F. LePage, W. Jiang, S. Abid, M. Hennig, A. Martinez, B. A. Wustman, D. J. Lockhart, R. Jain, R. A. Conlon, M. L. Drumm, C. A. Hodges, D. J. Siegwart*. In vivo editing of lung stem cells for durable gene correction in mice. Science, 2024, 384 (6701): 1196-1201. DOI: 10.1126/science.adk9428
21. X. Lian, S. Chatterjee, Y. Sun, S. Dilliard, S. Moore, Y. Xiao, X. Bian, K. Yamada, Y. Sung, R. Levine, K. Mayberry, S. John, X. Liu, C. Smith, L. Johnson, X. Wang, C. Zhang, D. Liu, G. Newby, M. Weiss, J. Yen, D. Siegwart*. Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells. Nature Nanotechnology, 2024, 19 (9), 1409–1417. DOI: 10.1038/s41565-024-01680-8
22. T. Wei, Y. Sun, Q. Cheng, S. Chatterjee, Z. Traylor, L. Johnson, M. Coquelin, J. Wang, M. Torres, X. Lian, X. Wang, Y. Xiao, C. Hodges, D. Siegwart*. Lung SORT LNPs enable precise homology-directed repair mediated CRISPR/Cas genome correction in cystic fibrosis models. Nature Communications, 2023, 14, 7322. DOI: 10.1038/s41467-023-42948-2
23. H. Liu, W. Chen, G. Wu, J. Zhou, C. Liu, Z. Tang, X. Huang, J. Gao, Y. Xiao, N. Kong, N. Joshi, Y. Cao, R. Abdi, Wei Tao*. Glutathione-scavenging nanoparticle-mediated PROTACs delivery for targeted protein degradation and amplified antitumor effects. Advanced Science, 2023, 10 (16): 2207439.DOI: 10.1002/advs.202207439
24. X. Huang, C. Liu, N. Kong, Y. Xiao, A. Yurdagul, I. Tabas, Wei Tao*. Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages. Nature Protocols, 2022, 17, 748–780. DOI: 10.1038/s41596-021-00665-4
25. Z. Tang, Y. Xiao, N. Kong, C. Liu, W. Chen, X. Huang, D. Xu, J. Ouyang, C. Feng, C. Wang, J. Wang*, H. Zhang*, W. Tao*. Nano-bio interfaces effect of two-dimensional nanomaterials and their applications in cancer immunotherapy. Acta Pharmaceutica Sinica B, 2021, 11 (11): 3447-3464. DOI: 10.1016/j.apsb.2021.05.004
26. X. Huang, G. Wu, C. Liu, X. Hua, Z. Tang, Y. Xiao, W. Chen, J. Zhou, N. Kong, P. Huang*, J. Shi*, W. Tao*. Intercalation-driven formation of siRNA nanogels for cancer therapy. Nano Letters. 2021, 21 (22): 9706–9714.DOI: 10.1021/acs.nanolett.1c03539
27. C. Liu, S. Sun, Q. Feng, G. Wu, Y. Wu, N. Kong, Z. Yu, J. Yao, X. Zhang, W. Chen, Z. Tang, Y. Xiao, X. Huang, A. Lv, C. Yao, H. Cheng, A. Wu*, T. Xie*, W. Tao*. Arsenene nanodots with selective killing effects and their low‐dose combination with ß‐elemene for cancer therapy. Advanced Materials, 2021, 33 (37): 2102054. DOI: 10.1002/adma.202102054
28. N. Kong, H. Zhang, C. Feng, C. Liu, Y. Xiao, X. Zhang, L. Mei, J. Kim, W. Tao*, X. Ji*. Arsenene-mediated multiple independently targeted reactive oxygen species burst for cancer therapy. Nature Communications, 2021, 12: 4777. DOI: 10.1038/s41467-021-24961-5
29. W. Chen, C. Liu, X. Ji, J. Joseph, Z. Tang, J. Ouyang, Y. Xiao, N. Kong, N. Joshi, O. C. Farokhzad*, W. Tao*, T. Xie*. Stanene-based nanosheets for β-elemene delivery and ultrasound-mediated combination cancer therapy. Angewandte Chemie International Edition, 2021, 60 (13): 7155. (Front Cover)DOI: 10.1002/anie.202016330
30. X. Ji, L. Ge, C. Liu, Z. Tang, Y. Xiao, W. Chen, Z. Lei, W. Gao, S. Blake, D. De, B. Shi, X. Zeng*, N. Kong*, X. Zhang*, W. Tao*. Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics. Nature Communications, 2021, 12, 1124. DOI: 10.1038/s41467-021-21436-5
31. C. Liu, J. Shin, S. Son, Y. Choe, N. Farokhzad, Z. Tang, Y. Xiao, N. Kong, T. Xie, J. Kim*, W. Tao*. Pnictogens in medicinal chemistry: evolution from erstwhile drugs to emerging layered photonic nanomedicine. Chemistry Society Review, 2021,50 (4): 2260-2279. DOI: 10.1039/d0cs01175d
32. J. Ouyang, Z. Tang, N. Farokhzad, N. Kong, N. Kim, C. Feng, S. Blake, Y. Xiao, C. Liu, T. Xie*, W. Tao*. Ultrasound mediated therapy: recent progress and challenges in nanoscience. Nano Today, 2020, 35: 100949. DOI: 10.1016/j.nantod.2020.100949
33. D. Liu, H. Sun, Y. Xiao, S. Chen, E. Cornel, Y. Zhu*, J. Du*. Design principles, synthesis and biomedical applications of polymer vesicles with inhomogeneous membranes. Journal of Controlled Release, 2020, 326: 365-386.DOI: 10.1016/j.jconrel.2020.07.018
34. S. Chen, S. Lin, Y. Xi, Y. Xiao, J. Du*. Polymersomes with inhomogeneous membranes, asymmetrical coronas and fused membranes and coronas. Chinese Science Bulletin, 2020, 65 (24): 2615-2626.DOI: 10.1360/TB-2020-0472
35. Y. Xi, Y. Wang, J. Gao, Y. Xiao, J. Du*. Dual corona vesicles with intrinsic antibacterial and enhanced antibiotic delivery capabilities for effective treatment of biofilm-induced periodontitis. ACS Nano, 2019, 13 (12): 13645–13657. DOI: 10.1021/acsnano.9b03237
36. H. Sun, J. Jiang, Y. Xiao, J. Du*. Efficient removal of polycyclic aromatic hydrocarbons, dyes, and heavy metal ions by a homopolymer vesicle. ACS Applied Materials & Interfaces, 2018, 10 (1): 713–722. DOI: 10.1021/acsami.7b15242
37. M. Wang, C. Zhou, J. Chen, Y. Xiao, J. Du*. Multifunctional biocompatible and biodegradable folic acid conjugated poly (ε-caprolactone)–polypeptide copolymer vesicles with excellent antibacterial activities. Bioconjugate Chemistry, 2015, 26 (4): 725–734. DOI: 10.1021/acs.bioconjchem.5b00061
38. T. Wang, J. Jiang, Y. Xiao, Y. Zou, J. Gao, J. Du. Preparation of polymersomes in pure water for facile antibacterial applications. RSC Advances, 2015, 5 (68), 55602-55607. DOI: 10.1039/c5ra10511k
专利
1. D. J. Siegwart, Y. Xiao. High density brush shaped polymer lipids reduce anti-PEG antibody binding to enable mRNA lipid nanoparticle repeat administration. Application 63/701,428.
2. W. Tao, Y. Xiao, Z. Tang, N. Kong. Glucose responsive insulin treatment platform. Application 63/249,630
3. 杜建忠;萧雨芬;胡宇; 一种血糖调控聚合物囊泡及其制备方法和应用, 2021-08-06, 中国, ZL2019 1 0008450.8
4. 杜建忠;孙辉;萧雨芬;一种具有糖海绵功能的聚合物囊泡的制备方法和应用, 2017-08-25, 中国, ZL 2015 1 0458716.0
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